"When and Where?": Behavior Dominant Location Forecasting with Micro-blog Streams

The proliferation of smartphones and wearable devices has increased the availability of large amounts of geospatial streams to provide significant automated discovery of knowledge in pervasive environments, but most prominent information related to altering interests have not yet adequately capitalized. In this paper, we provide a novel algorithm to exploit the dynamic fluctuations in user's point-of-interest while forecasting the future place of visit with fine granularity. Our proposed algorithm is based on the dynamic formation of collective personality communities using different languages, opinions, geographical and temporal distributions for finding out optimized equivalent content. We performed extensive empirical experiments involving, real-time streams derived from 0.6 million stream tuples of micro-blog comprising 1945 social person fusion with graph algorithm and feed-forward neural network model as a predictive classification model. Lastly, The framework achieves 62.10% mean average precision on 1,20,000 embeddings on unlabeled users and surprisingly 85.92% increment on the state-of-the-art approach.Comment: Accepted as a full paper in the 2nd International Workshop on Social Computing co-located with ICDM, 2018 Singapor

Machine learning-based identification of colon cancer candidate diagnostics genes

SIMPLE SUMMARY: We developed a predictive approach using different machine learning methods to identify a number of genes that can potentially serve as novel diagnostic colon cancer biomarkers. ABSTRACT: Background: Colorectal cancer (CRC) is the third leading cause of cancer-related death and the fourth most commonly diagnosed cancer worldwide. Due to a lack of diagnostic biomarkers and understanding of the underlying molecular mechanisms, CRC’s mortality rate continues to grow. CRC occurrence and progression are dynamic processes. The expression levels of specific molecules vary at various stages of CRC, rendering its early detection and diagnosis challenging and the need for identifying accurate and meaningful CRC biomarkers more pressing. The advances in high-throughput sequencing technologies have been used to explore novel gene expression, targeted treatments, and colon cancer pathogenesis. Such approaches are routinely being applied and result in large datasets whose analysis is increasingly becoming dependent on machine learning (ML) algorithms that have been demonstrated to be computationally efficient platforms for the identification of variables across such high-dimensional datasets. Methods: We developed a novel ML-based experimental design to study CRC gene associations. Six different machine learning methods were employed as classifiers to identify genes that can be used as diagnostics for CRC using gene expression and clinical datasets. The accuracy, sensitivity, specificity, F1 score, and area under receiver operating characteristic (AUROC) curve were derived to explore the differentially expressed genes (DEGs) for CRC diagnosis. Gene ontology enrichment analyses of these DEGs were performed and predicted gene signatures were linked with miRNAs. Results: We evaluated six machine learning classification methods (Adaboost, ExtraTrees, logistic regression, naïve Bayes classifier, random forest, and XGBoost) across different combinations of training and test datasets over GEO datasets. The accuracy and the AUROC of each combination of training and test data with different algorithms were used as comparison metrics. Random forest (RF) models consistently performed better than other models. In total, 34 genes were identified and used for pathway and gene set enrichment analysis. Further mapping of the 34 genes with miRNA identified interesting miRNA hubs genes. Conclusions: We identified 34 genes with high accuracy that can be used as a diagnostics panel for CRC